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Writer's pictureshannonkaneshige
May 16, 20214 min read

Rhabdoid Tumor Information

Websites 

READ ME FIRST: Please take care when accessing these sites. Most do contain survival rates. I caution parents of children diagnosed with MRT to remember that statistics are not truths. No one can tell you how your child will respond to treatment. 

News Articles 


P53 in Relation to SMARB1- Tumors

Researchers at The University of Texas MD Anderson Cancer Center have discovered that malignant rhabdoid tumors (MRT), a rare pediatric cancer without effective treatments, may be sensitive to drugs that block the cancer cell's ability to dispose of misfolded proteins. The findings provide a much-needed therapeutic target for these and other cancers caused by mutations in the SMARCB1 gene.


PGBD5

A new discovery published in the journal Nature Genetics identifies a mechanism for the triggering of solid tumors — including most types of cancers that affect children and young adults. The enzyme made by the gene PGBD5 cuts DNA segments and then rearranges them. This DNA remodeling can drastically alter normal gene function and cause cancer. Rather than normal cells turning cancerous as a result of random errors or mutations, the molecule encoded by the PGBD5 gene itself can induce specific mutations and turn cells malignant. Jumping Genes and the Dark Genome: MSK Researchers Gain New Insight into Childhood Cancers

Medical Papers

Warning: These academic papers often detail poor outcomes. Do not lose hope!! Statistics cannot tell you what your child's outcome will be.  Hopefully this research will lead to treatments that can make this disease manageable, if not provide a cure. This is by no means a comprehensive list of papers, simply what I have come by in my own research of my son's MRT.

Liver, AT/RT and Extrarenal Tumors

Genetics of Rhabdoid Tumors

Liver Tumors: 


General Tumor Information:

Abstracts:

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